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hal.structure.identifier
dc.contributor.authorStigliani, Sara
hal.structure.identifierLaboratoire d'analyse et modélisation de systèmes pour l'aide à la décision [LAMSADE]
dc.contributor.authorMoretti, Stefano
HAL ID: 739814
ORCID: 0000-0003-3627-3257
hal.structure.identifier
dc.contributor.authorAnserini, Paola
hal.structure.identifier
dc.contributor.authorCasciano, Ida
hal.structure.identifier
dc.contributor.authorVenturini, Pier Luigi
hal.structure.identifier
dc.contributor.authorScaruffi, Paola
dc.date.accessioned2016-12-01T16:54:41Z
dc.date.available2016-12-01T16:54:41Z
dc.date.issued2015
dc.identifier.issn0268-1161
dc.identifier.urihttps://basepub.dauphine.fr/handle/123456789/16033
dc.language.isoenen
dc.subjecthuman MII oocyteen
dc.subjectslow freezing cryopreservationen
dc.subjectstorage timeen
dc.subjectmicroarrayen
dc.subjectgene expressionen
dc.titleStorage time does not modify the gene expression profile of cryopreserved human metaphase II oocytesen
dc.typeArticle accepté pour publication ou publié
dc.description.abstractenSTUDY QUESTION Does storage time have any impact on the transcriptome of slowly frozen cryopreserved human metaphase II (MII) oocytes? SUMMARY ANSWER: The length of cryostorage has no effect on the gene expression profile of human MII oocytes. WHAT IS KNOWN ALREADY: Oocyte cryopreservation is a widely used technique in IVF for storage of surplus oocytes, as well as for fertility preservation (i.e. women undergoing gonadotoxic therapies) and oocyte donation programs. Although cryopreservation has negative impacts on oocyte physiology and it is associated with decrease of transcripts, no experimental data about the effect of storage time on the oocyte molecular profile are available to date. STUDY DESIGN, SIZE, DURATION: This study included 27 women, ≤38 years aged, without any ovarian pathology, undergoing IVF treatment. Surplus MII oocytes were donated after written informed consent. A total of 31 non-cryopreserved oocytes and 68 surviving slow-frozen/rapid-thawed oocytes (32 oocytes cryostored for 3 years and 36 cryostored for 6 years) were analyzed.en
dc.relation.isversionofjnlnameHuman reproduction
dc.relation.isversionofjnlvol30en
dc.relation.isversionofjnlissue11en
dc.relation.isversionofjnldate2015-09
dc.relation.isversionofjnlpages2519-2526en
dc.relation.isversionofdoi10.1093/humrep/dev232en
dc.subject.ddclabelMaladiesen
dc.relation.forthcomingnonen
dc.relation.forthcomingprintnonen
dc.description.ssrncandidatenonen
dc.description.halcandidateouien
dc.description.readershiprechercheen
dc.description.audienceInternationalen
dc.relation.Isversionofjnlpeerreviewedouien
dc.relation.Isversionofjnlpeerreviewedouien
dc.date.updated2016-11-16T10:52:31Z
hal.identifierhal-01407051*
hal.version1*
hal.author.functionaut
hal.author.functionaut
hal.author.functionaut
hal.author.functionaut
hal.author.functionaut
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