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Low income and outcome in idiopathic pulmonary fibrosis: An association to uncover

hal.structure.identifierService de pneumologie [Avicenne]
dc.contributor.authorSesé, Lucile
dc.contributor.authorCaliez, Julien
hal.structure.identifierInstitut Desbrest de santé publique [IDESP]
dc.contributor.authorAnnesi-Maesano, Isabella
hal.structure.identifierCIC CHU Lyon (inserm)
hal.structure.identifierCentre de Référence des Maladies Pulmonaires Rares [Hôpital Louis Pradel - HCL]
dc.contributor.authorCottin, Vincent
hal.structure.identifierInstitut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
hal.structure.identifierPhysiopathologie et Epidémiologie des Maladies Respiratoires [PHERE (UMR_S_1152 / U1152)]
dc.contributor.authorPesce, Giancarlo
hal.structure.identifierCentre de référence maladies rares des maladies pulmonaires rares de l’adulte (CHU Dijon) [CRMR des maladies pulmonaires rares de l’adulte]
dc.contributor.authorDidier, Morgane
hal.structure.identifierService de pneumologie [Avicenne]
dc.contributor.authorCarton, Zohra
hal.structure.identifierService de Pneumologie, soins intensifs [Pneumo - HEGP]
dc.contributor.authorIsrael-Biet, Dominique
hal.structure.identifierCIC - CHU Bichat
hal.structure.identifierService de Pneumologie A [Paris]
dc.contributor.authorCrestani, Bruno
dc.contributor.authorGuillot Dudoret, Stéphanie
hal.structure.identifierCentre de référence maladies rares des maladies pulmonaires rares de l’adulte (CHU Dijon) [CRMR des maladies pulmonaires rares de l’adulte]
dc.contributor.authorCadranel, Jacques
hal.structure.identifierHôpital Albert Calmette
hal.structure.identifierService de Pneumologie et Immuno-Allergologie [CHU LIlle]
dc.contributor.authorWallaert, Benoit
hal.structure.identifierImmunologie humaine, physiopathologie & immunothérapie [HIPI (UMR_S_976 / U976)]
dc.contributor.authorTazi, Abdellatif
hal.structure.identifierService de physiologie, explorations fonctionnelles [Mondor]
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorMaître, Bernard
hal.structure.identifierService de pneumologie [Toulouse]
dc.contributor.authorPrévot, Grégoire
hal.structure.identifierCHU Trousseau [Tours]
hal.structure.identifierCentre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 [CEPR]
dc.contributor.authorMarchand-Adam, Sylvain
dc.contributor.authorHirschi, Sandrine
dc.contributor.authorDury, Sandra
dc.contributor.authorGiraud, Violaine
dc.contributor.authorGondouin, Anne
hal.structure.identifierService des maladies respiratoires [CHU de Dijon]
hal.structure.identifierService de Pneumologie Soins Intensifs, Appareillage Respiratoire [CHU de Dijon]
dc.contributor.authorBonniaud, Philippe
hal.structure.identifierCIC CHU Lyon (inserm)
hal.structure.identifierCentre de Référence des Maladies Pulmonaires Rares [Hôpital Louis Pradel - HCL]
dc.contributor.authorTraclet, Julie
dc.contributor.authorJuvin, Karine
hal.structure.identifierCIC - CHU Bichat
hal.structure.identifierService de Pneumologie A [Paris]
dc.contributor.authorBorie, Raphael
hal.structure.identifierService de pneumologie [Avicenne]
dc.contributor.authorBernaudin, Jean-François
hal.structure.identifierService de pneumologie [Avicenne]
dc.contributor.authorValeyre, Dominique
hal.structure.identifierInstitut de Recherche Interdisciplinaire en Sciences Sociales [IRISSO]
dc.contributor.authorCavalin, Catherine
hal.structure.identifierService de pneumologie [Avicenne]
dc.contributor.authorNunes, Hilario
dc.contributor.authorCOFI Collaborators, C.
dc.date.accessioned2021-10-05T12:31:13Z
dc.date.available2021-10-05T12:31:13Z
dc.date.issued2021
dc.identifier.issn0954-6111
dc.identifier.urihttps://basepub.dauphine.psl.eu/handle/123456789/21925
dc.language.isoenen
dc.subjectIdiopathic pulmonary fibrosisen
dc.subjectSocioeconomic statusen
dc.subjectIncomeen
dc.subjectAir pollutionen
dc.subjectOccupational exposureen
dc.subject.ddc305en
dc.titleLow income and outcome in idiopathic pulmonary fibrosis: An association to uncoveren
dc.typeArticle accepté pour publication ou publié
dc.description.abstractenBackgroundLow income, a known prognostic indicator of various chronic respiratory diseases, has not been properly studied in idiopathic pulmonary fibrosis (IPF). We hypothesize that a low income has an adverse prognostic impact on IPF.MethodsPatients were selected from the French national prospective cohort COFI. Patients’ income was assessed through the median city-level income provided by the French National Institute of Statistics and Economic Studies according to their residential address. Patients were classified in two groups as “low income” vs. “higher income” depending on whether their annual income was estimated to be < or ≥18 170 €/year (the first quartile of the income distribution in the study population). The survival and progression-free survival (PFS) of the groups were compared by a log-rank test and a Cox model in multivariate analysis.Results200 patients were included. The average follow-up was 33.8 ± 22.7 months. Patients in the low income group were significantly more likely to be of non-European origin (p < 0.006), and to have at least one occupational exposure (p < 0.0001), and they tended to have a higher cumulative exposure to fine particles PM2.5 (p = 0.057). After adjusting for age, gender, forced vital capacity at inclusion, geographical origin, and occupational exposure having a low-income level was a factor associated with a worse PFS (HR: 1.81; CI95%: 1.24–2.62, p = 0.001) and overall survival (HR: 1.49; CI95%: 1.0006–2.23, p = 0.049).ConclusionsLow income appears to be a prognostic factor in IPF. IPF patients with low incomes may also be exposed more frequently to occupational exposures.en
dc.relation.isversionofjnlnameRespiratory Medicine
dc.relation.isversionofjnlvol183en
dc.relation.isversionofjnldate2021
dc.relation.isversionofjnlpages106415en
dc.relation.isversionofdoi10.1016/j.rmed.2021.106415en
dc.relation.isversionofjnlpublisherElsevieren
dc.subject.ddclabelStructure de la sociétéen
dc.relation.forthcomingnonen
dc.description.ssrncandidatenon
dc.description.halcandidateouien
dc.description.readershiprechercheen
dc.description.audienceInternationalen
dc.relation.Isversionofjnlpeerreviewedouien
dc.date.updated2021-09-24T16:23:36Z
hal.identifierhal-03365969
hal.version1
hal.date.transferred2021-10-05T12:31:16Z
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