A Preliminary Comparison of P-Tool Consistency

Murillo, Javier; Spetale, Flavio; Tapia, Elizabeth; Krsticevic, Flavia; Cailloux, Olivier; Guillaume, Serge; Vazquez, Gustavo; Fernandez, Tamara; Destercke, S.; Ponce, Sergio; Bulacio, P.

Murillo, Javier; Spetale, Flavio; Tapia, Elizabeth; Krsticevic, Flavia; Cailloux, Olivier; Guillaume, Serge; Vazquez, Gustavo; Fernandez, Tamara; Destercke, S.; Ponce, Sergio; Bulacio, P. (2020), A Preliminary Comparison of P-Tool Consistency, in González Díaz, César A.; Chapa González, Christian; Laciar Leber, Eric, VIII Latin American Conference on Biomedical Engineering and XLII National Conference on Biomedical Engineering, Springer, p. 731-735. 10.1007/978-3-030-30648-9_97

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Type

Communication / Conférence

Date

2020

Conference title

Proceedings of CLAIB-CNIB 2019

Conference date

2019-10

Conference city

Cancún

Conference country

Mexico

Book title

VIII Latin American Conference on Biomedical Engineering and XLII National Conference on Biomedical Engineering

Book author

González Díaz, César A.; Chapa González, Christian; Laciar Leber, Eric

Publisher

Springer

ISBN

978-3-030-30648-9

Number of pages

1518

Pages

731-735

Abstract (EN)

Many Bioinformatics tools, known as p-tools, have been developed to predict the effect of single nucleotide polymorphisms (SNPs) on gene functionality, in an effort to reduce the need for in-vivo assays. However, the large number of p-tools available and the heterogeneity of their output make their selection and comparison difficult. To study the consistency of predictions across p-tools, here we present two indices and test them on five p-tools whose predictions are based on different types of background information. For this test, SNPs from well-known organism Drosophila melanogaster are considered.

Subjects / Keywords

SNP; Gene functionality; Missense nonsense mutation