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Coalitional games on biological networks to measure the power of genes

Moretti, Stefano; Fragnelli, Vito; Patrone, Fioravante; Bonassi, Stefano (2010), Coalitional games on biological networks to measure the power of genes, 24th European Conference on Operational Research, 2010-07, Lisbonne, Portugal

Type
Communication / Conférence
Date
2010
Conference title
24th European Conference on Operational Research
Conference date
2010-07
Conference city
Lisbonne
Conference country
Portugal
Metadata
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Author(s)
Moretti, Stefano cc
Fragnelli, Vito
Patrone, Fioravante
Bonassi, Stefano
Abstract (EN)
The interpretation of gene interaction in biological networks generates the need for a meaningful ranking of network elements. We introduce a new approach using coalitional games to evaluate the centrality of genes in networks keeping into account genes interactions. The Shapley value for coalitional games is used to express the power of each gene in interaction with the others and to stress the centrality of certain hub genes in the regulation of biological pathways of interest. In addition, the new approach allows for the integration of a priori knowledge about genes.
Subjects / Keywords
gene interaction; biological networks; coalitional games
JEL
C73 - Stochastic and Dynamic Games; Evolutionary Games; Repeated Games
C71 - Cooperative Games