Show simple item record

dc.contributor.authorCoco, Simona
dc.contributor.authorTruini, Mauro
dc.contributor.authorMirisola, Valentina
dc.contributor.authorFalugi, Carla
dc.contributor.authorDi Candia, Michele
dc.contributor.authorScaruffi, Paola
dc.contributor.authorMoretti, Stefano
HAL ID: 739814
ORCID: 0000-0003-3627-3257
dc.contributor.authorBrizzolara, Antonella
dc.contributor.authorAlbino, Domenico
dc.contributor.authorTonini, Gian Paolo
dc.subjectDNA Repair Genesen
dc.subjectNeural Crest Cellsen
dc.titleGene Expression Profiling Identities Eleven DNA Repair Genes Down Regulated During Mouse Neural Crest Cell Migrationen
dc.typeArticle accepté pour publication ou publié
dc.description.abstractenNeural Crest Cells (NCCs) are a transient multipotent migratory cells that derive from embryonic neural crest structure and in turn neural crest derives from the margin of the neural tube. DNA repair genes have been shown to be expressed in the early stages of mammalian development probably to reduce possible replication errors and genotoxic damages. Several birth defects and some cancers are due to inappropriate or defective DNA repair machinery indicating that a right activity of DNA repair genes in the early stages of fetal development is essential for an appropriate DNA function. A complete profile of DNA repair genes during embryo development has not been yet assess. We performed a genome-wide gene expression analysis by high-density oligo-microarray of mouse NCCs at E8.5, at E13.3 and at P90 and we found 11 genes involved in DNA repair activity overexpressed in the early stages of mouse embryo development whereas their expression become undetectable in the adrenal medulla of adult mouse. Among the 11 genes, 6 were never been observed high expressed in mouse embryology. Our results suggest that high expression of NCCs DNA repair genes in early embryonal stages needs to maintain DNA integrity. Failure of some of these genes may be associated to both genetic and cancer diseases.en
dc.relation.isversionofjnlnameThe International Journal of Developmental Biology
dc.relation.isversionofjnlpublisherUBC Pressen
dc.subject.ddclabelAnatomie, cytologie, histologie humainesen

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record