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A Multiple target approach for single quantum dot tracking

Dahan, Maxime; Cohen, Laurent D.; Bonneau, Stéphane (2005), A Multiple target approach for single quantum dot tracking, Biomedical Imaging: Nano to Macro, 2004. IEEE International Symposium on, IEEE, p. 664-667. http://dx.doi.org/10.1109/ISBI.2004.1398625

Type
Communication / Conférence
Date
2005
Conference title
Biomedical Imaging: Nano to Macro, 2004. IEEE International Symposium on
Conference date
2004-04
Conference city
Washington (DC)
Conference country
Etats-Unis
Book title
Biomedical Imaging: Nano to Macro, 2004. IEEE International Symposium on
Publisher
IEEE
ISBN
0-7803-8388-5
Pages
664-667
Publication identifier
Metadata
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Author(s)
Dahan, Maxime
Cohen, Laurent D.
Bonneau, Stéphane
Abstract (EN)
Semiconductor quantum dots (QDs) are nanometer-sized fluorescent particles with a great promise for advanced biological imaging. They have recently been shown to be very favorable probes for ultrasensitive detection. When specifically attached to a biomolecule of interest, they allow for single molecule tracking in live cells over unprecedented durations and open new prospects for the study of cellular dynamics. We present an algorithm for automatically detecting and tracking QDs in sequences of fluorescence images. It accounts for the blinking in the fluorescence signal of individual QDs assuming Brownian dynamics of the biomolecules. Our algorithm analyzes images sequentially and can be extended to a real-time use.
Subjects / Keywords
Biologie; Modèles mathématiques