Show simple item record

dc.contributor.authorUmuhire, D
dc.contributor.authorDenis, Philippe
HAL ID: 19566
dc.contributor.authorLe Pen, Claude
dc.contributor.authorBerdeaux, Gilles
dc.subjectDES modelen
dc.subjectdiscrete event simulationen
dc.titleTreatment carryover impacts on effectiveness of intraocular pressure lowering agents, estimated by a discrete event simulation model.en
dc.typeArticle accepté pour publication ou publié
dc.description.abstractenPURPOSE: To compare the effectiveness of two treatment sequences, latanoprost-latanoprost timolol fixed combination (L-LT) versus travoprost-travoprost timolol fixed combination (T-TT), in the treatment of open-angle glaucoma (OAG) or ocular hypertension (OHT). METHODS: A discrete event simulation (DES) model was constructed. Patients with either OAG or OHT were treated first-line with a prostaglandin, either latanoprost or travoprost. In case of treatment failure, patients were switched to the specific prostaglandin-timolol sequence LT or TT. Failure was defined as intraocular pressure higher than or equal to 18 mmHg at two visits. Time to failure was estimated from two randomized clinical trials. Log-rank tests were computed. Linear functions after log-log transformation were used to model time to failure. The time horizon of the model was 60 months. Outcomes included treatment failure and disease progression. Sensitivity analyses were performed. RESULTS: Latanoprost treatment resulted in more treatment failures than travoprost (p<0.01), and LT more than TT (p<0.01). At 60 months, the probability of starting a third treatment line was 39.2% with L-LT versus 29.9% with T-TT. On average, L-LT patients developed 0.55 new visual field defects versus 0.48 for T-TT patients. The probability of no disease progression at 60 months was 61.4% with L-LT and 65.5% with T-TT. CONCLUSIONS: Based on randomized clinical trial results and using a DES model, the T-TT sequence was more effective at avoiding starting a third line treatment than the L-LT sequence. T-TT treated patients developed less glaucoma progression.en
dc.relation.isversionofjnlnameEuropean Journal of Ophthalmology
dc.relation.isversionofjnlpublisherWichtig Editoreen
dc.subject.ddclabelEconomie socialeen

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record